Genomics and Epigenetics with 2D material Nano-Electronics

23/01/2017 @ 2:00 PM – 4:00 PM Asia/Singapore Timezone
S16 Level 6 – Theory conference room

Speaker: Dr. Jean-Pierre Leburton
Affiliation: University of Illinois, USA
Abstract Details: This talk is part of a monthly workshop with clinicians organized jointly with Prof. C. N. Lee , Chairman, University Surgical Cluster, National University Health System (NUHS), to explore how 2D materials can address urgent needs in biomedical research. Exciting development of new materials has opened up novel possibilities in bio-medical applications. The clinical needs are varied. Major areas need better materials: e.g. Non clotting surfaces which are bio-compatible, able to withstand shear stress forces of blood flows, able to tolerate binding if needed; materials which can be implanted into 2mm diameter coronary arteries without causing scarring reaction, with no tissue ingrowth; materials that can prevent bacteria from fouling or colonising implanted devices or catheters. Stents used in the airways, intestines bile ducts, brain cavities that remains open for longer periods. Similarly new materials are needed to achieve novel bio sensing capabilities . Through regular interactions between clinicians and material engineers, it would be possible to come to closer understanding of the needs and the options available. This series of talks aim to set up structures in collaboration, development, testing, refinement, animal and clinical trials, product development, and reaching the patients by commercialization. Q&A (2pm - 3:30 pm) Prof Lee and the speaker will stay after the talk to answer and discuss with interested students, postdocs and PI potential areas of collaborations between the various groups at NUS.”Abstract

Dr. Jean-Pierre Leburton will review some basic properties of cell biology, and present a scenario that integrates biology with MOS nano-electronics for genomics and bio-medical applications. This scenario involves probing the electrical activity of biomolecules passing through a nanopore, in a semiconductor membrane. Among solid-state porous membranes the use of the single-atom thickness of graphene or novel 2D materials like MoS2 are ideally suited for DNA, RNA or proteins sensing as they can scan molecules passing through a nanopore at high resolution.  Additionally, unlike most biological membranes, these new materials are electrically active, which can be exploited to manipulate in addition to sense biomolecules. We will describe a membrane designed as a quantum point contact FET as a viable device for electronically and optically sensing bio-molecules for applications in genomics and cancer detection.

About the Speaker: Dr. Leburton joined the University of Illinois in 1981 from Germany, where he worked as a research scientist with the Siemens A.G. Research Laboratory in Munich. In 1992, he held the Hitachi LTD Chair on Quantum Materials at the University of Tokyo, and was a Visiting Professor in the Federal Polytechnic Institute in Lausanne, Switzerland in 2000. He is involved with research in nanostructures modeling and in quantum device simulation. His present research interest encompasses non-linear transport in quantum wires and carbon nanotubes, and molecular and bio-nanoelectronics

Professor Leburton is author and co-author of more than 300 technical papers in international journals and books, and served in numerous conferences committees. In 1993 he was awarded the title of “Chevalier dans l’Ordre des Palmes Academiques “ by the French Government. He is a Fellow of the Institute of Electrical and Electronic Engineers (IEEE), the American Physical Society (APS), the Optical Society of America (OSA), the American Association for the Advancement of Science (AAAS), the Electrochemical Society (ECS) and the Institute of Physics (IOP). He is also a member of the New York Academy of Science. In 2004 he was the recipient of the ISCS Quantum Device Award, and of the Gold medal for scientific achievement by the Alumnus association of the University of Liege, Belgium. He is a Distinguished Lecturer for the IEEE Nanotechnology Council. In 2011 he was elected to Royal Academy of Sciences of Belgium.