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Nano-bio interactions between carbon nanomaterials and blood plasma proteins: why oxygen functionality matters

TitleNano-bio interactions between carbon nanomaterials and blood plasma proteins: why oxygen functionality matters
Publication TypeJournal Article
Year of Publication2017
Authors, Geldert Alisha, Liu Yanpeng, Loh Kian Ping, and Lim Chwee Teck
JournalNPG Asia Mater.
Volume9
Paginatione422
Date Published08/2017
ISSN1884-4049
Keywordscomposites, future, graphene-family nanomaterials, interface, nanoparticles, Nanotubes, oxide, surface-properties
Abstract

Carbon nanomaterials are some of the most versatile nanomaterials. Along with increasing explorations into their utilization in a plethora of biological and biomedical applications, there have been emerging interests and needs in understanding the molecular hemocompatibility of these engineered nanomaterials when coming into contact with blood. Here, we evaluate the nano-bio interactions of one-dimensional (1D) and two-dimensional (2D) carbon nanomaterials with blood plasma proteins. Different facets of the nanomaterial-protein interactions, specifically, the adsorption, equilibrium binding and conformational stability of proteins upon association with carbon nanomaterials are established, based on the quantification of various parameters, such as association constant, binding cooperativity and protein secondary structural change. In light of our data, we demonstrate that the carbon nanomaterial-plasma protein interactions may be significantly influenced by the density of the oxygenated functionalities of the nanomaterials and to a certain extent, their dimensionality and surface area. This work offers a broad insight into the nano-bio interactions between carbon nanomaterials and blood plasma proteins and provides a strong basis for the design and use of 1D and 2D carbon nanomaterials for a wide variety of bioapplications.

DOI10.1038/am.2017.129

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