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Graphenes: Opportunities for bone engineering and development of orthopaedic material

Dr. Vinicius Rosa (Assistant Professor, Oral Sciences, Faculty of Dentistry/NUS)
Fri, 25/11/2016 - 4:00pm to 6:00pm
CA2DM Theory Common (S16-06)
Prof. Barbaros Oezyilmaz
Event Type: 

“Dr Vinicius’ talk is part of a monthly workshop with clinicians organized jointly with Prof. C. N. Lee , Chairman, University Surgical Cluster, National University Health System (NUHS), to explore how 2D materials can address urgent needs in biomedical research. Exciting development of new materials has opened up novel possibilities in medical applications. The clinical needs are varied. Major areas need better materials: e.g. Non clotting surfaces which are bio-compatible, able to withstand shear stress forces of blood flows, able to tolerate binding if needed; materials which can be implanted into 2mm diameter coronary arteries without causing scarring reaction, with no tissue ingrowth; materials that can prevent bacteria from fouling or colonising implanted devices or catheters. Stents used in the airways, intestines bile ducts, brain cavities that remains open for longer periods. Through regular interactions between clinicians and material engineers, it would be possible to come to closer understanding of the needs and the options available. This series of talks aim to set up structures in collaboration, development, testing, refinement, animal and clinical trials, product development, and reaching the patients by commercialization. Q&A (4.45pm - 6.00pm) Prof Lee and Dr. Vinicius will stay after the talk to answer discuss with interested students, postdocs and PI potential areas of collaborations between the various groups at NUS.”


The global market for bone graft substitutes will worth US$ 3.2 billion in 2022. The market for hip and knee orthopaedic surgical joint replacement products is expected to reach US $33 billion in the same year. Hence, the development of materials and strategies that can promote faster healing of prosthetic devices and improved regeneration of bony defects is of high interest. Graphene and its derivatives (graphene oxide and reduced graphene oxide) have remarkable mechanical properties, can be chemically modified and allow the attachment of molecules and proteins. Due to these characteristics, these carbon-based materials have received increasing attention for several biomedical applications. As graphenes can improve mechanical properties of several biomaterials, induce, and increase cell differentiation towards osteoblasts, they have emerged as alternatives to promote bone regeneration. In this seminar, Dr. Rosa will discuss the key achievements made with graphenes for bone tissue engineering and the possible graphene-mediated mechanisms leading to the enhanced regeneration. 

About the Speaker

Dr. Vinicius ROSA

Assistant Professor, Oral Sciences, Faculty of Dentistry, NUS.

Faculty, Centre for Advanced 2D Materials and Graphene Research Centre, NUS.

Dr. Rosa obtained D.D.S. (Doctor of Dental Surgery) in 2005 and has received the "Academy of Dental Materials Student Award", an award presented by the Academy of Dental Materials to the most outstanding student researcher in the field of Dental Materials. In 2007, the M.Sc. dissertation on the deterioration of strength of bioceramics received the George C. Paffenbarger Research Award that recognizes the best paper in the field of Dental Materials annually. In 2010, Dr. Rosa defended the Ph.D. thesis “Dental Pulp Tissue Engineering in Full-length Human Root Canals” and started studying the interactions of material with cells and host living tissue. The article arising from it thesis is in the top 1% globally for Dentistry and has received the Edward H. Hatton Award. In 2012, Dr. Rosa joined Faculty of Dentistry/NUS to develop with novel cell models and materials for tissue regeneration. In 2014, Dr. Rosa was appointed as a Faculty by the Centre for Advanced 2D Materials and Graphene Research Centre /NUS where focus on the use of graphene to improve bone tissue tissue engineering and regeneration.

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